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اسید نوکلئیک
Nucleic Acids Res. 40, e2 (2012).
Nucleic Acids Res. 44, e105 (2016).
Indeed, the rapid turnover of cancer cells is postulated to result in the constant release of tumourderived nucleic acids and vesicles into the
Exosomes have important roles in exchanging molecular information between cells: they have been shown to contain proteins as well as a range of nucleic acids, including DNA, mRNAs, and miRNAs, suggesting that they can modulate the activity of the recipient cells38,39.
The existence of cfDNA was first described in 1948 by Mandel and Metais56, who detected noncellbound nucleic acids in the bloodstream of individuals with cancer.
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